Noiseware is a high-performance noise suppression software tool designed to decrease or eliminate noise from digital photo or scanned images. Unlike most image processing software techniques that utilize simple methods (such as median filters) to treat digital noise in images, Noiseware features a sophisticated yet fast noise filtering algorithm.
Using the adaptive noise profile capability and sharpening function, Noiseware greatly reduces the visible noise while keeping the details in the images. I have used Noiseware as a plugin for Adobe Photoshop and I tell you, it is one of my most used plugins because of its effectiveness in really removing noise in images while still leaving the subjects un-blurred.
I tried Topaz DeNoise but I prefer the results of Imagenomic NoiseWare even better. Well, way better. Plus, it is so easy to use. You can just use the pre-defined presets included or you can tweak the settings manually. Either way, the result is impressive.